Again, this is rather a complex scientific notion for most of us (well, me!), but in short the idea is to identify other genes which, when mutated, somehow protect an individual from a MeCP2 mutation.
There are people who have common MECP2 mutations and normal X chromosome inactivation who do not have Rett Syndrome. Identifying which genes protect some people from developing Rett Syndrome – known as ‘modifier genes’ – could open up new avenues for treatment.
Read more about this approach at: